UnknownNot Applicable

The Role of the Microbiota-gut-brain Axis in Brain Development and Mental Health

United Kingdom120 participantsStarted 2019-02-01

Plain-language summary

The role of the microbiota-gut-brain axis in brain development and mental health

Who can participate

Age range18 Years – 25 Years

SexFEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Females * Aged between 18-25 Exclusion Criteria: * Clinical levels of anxiety and/ or co-morbid diagnoses (e.g. depression) * Current or previous neurological disorders * Current or previous psychiatric disorders * Current or previous gastrointestinal disorders * Current or previous endocrine disorders * Antibiotic use 3 months prior to the study * Regular use of pre- and probiotics, including 3 months prior to the study * Vegan diets

What they're measuring

Changes in brain indices of emotion regulation abilities as a function of prebiotic intake 1

Timeframe: 4 weeks of intervention

Changes in brain indices of emotion regulation abilities as a function of prebiotic intake 2

Timeframe: 4 weeks of intervention

Changes in psychological measures of emotion regulation abilities as a function of prebiotic intake 1

Timeframe: 4 weeks of intervention

Changes in psychological measures of emotion regulation abilities as a function of prebiotic intake 2

Timeframe: 4 weeks of intervention

Changes in psychological measures of emotion regulation abilities as a function of prebiotic intake 3

Timeframe: 4 weeks of intervention

Changes in gut microbiome composition as a function of prebiotic intake

Timeframe: 4 weeks of intervention

Changes in gut microbiome composition as a function of prebiotic intake

Timeframe: 4 weeks of intervention

Trial details

NCT IDNCT03835468

SponsorUniversity of Surrey

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-03

Contact for this trial

Kathrin Cohen Kadosh, PhD

01483 68 3968 k.cohenkadosh@surrey.ac.uk

View on ClinicalTrials.gov More Gamma-Aminobutyric Acid trials

Who can participate

Age range18 Years – 25 Years

SexFEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Changes in brain indices of emotion regulation abilities as a function of prebiotic intake 1

Timeframe: 4 weeks of intervention

Changes in brain indices of emotion regulation abilities as a function of prebiotic intake 2

Timeframe: 4 weeks of intervention

Changes in psychological measures of emotion regulation abilities as a function of prebiotic intake 1

Timeframe: 4 weeks of intervention

Changes in psychological measures of emotion regulation abilities as a function of prebiotic intake 2

Timeframe: 4 weeks of intervention

Changes in psychological measures of emotion regulation abilities as a function of prebiotic intake 3

Timeframe: 4 weeks of intervention

Changes in gut microbiome composition as a function of prebiotic intake

Timeframe: 4 weeks of intervention

Changes in gut microbiome composition as a function of prebiotic intake

Timeframe: 4 weeks of intervention