Omega 3 Fatty Acids in Colorectal Cancer (CRC) Prevention in Patients With Lynch Syndrome (COLYNE)

Inclusion Criteria: * Ability of participant or Legally Authorized Representative (LAR) to understand this study, and participant or LAR willingness to sign a written informed consent * Candidate for elective endoscopy procedure * Participants with known Lynch Syndrome * Eastern Cooperative Oncology Group (ECOG) Performance Status 0-1 * Willing to undergo a colonoscopy and biopsy at baseline and another colonoscopy and biopsy at 12 months visit. * Participants taking Aspirin for chemoprevention must agree to stop it for at least 4 weeks prior to study entry and throughout the trial period * Adequate organ and marrow function * Women of child-bearing potential and men with partners of child-bearing potential must agree to practice sexual abstinence, or to use two forms of adequate contraception (hormonal AND barrier method of birth control) prior to study entry, for the duration of study participation, and for 90 days following completion of therapy. If a woman becomes pregnant or suspects she is pregnant while participating in this study, she should inform her treating physician immediately. * Men of child-bearing potential must not father a child or donate sperm while on this study and for 90 days after their last study treatment. Exclusion Criteria: * Current or anticipated use of other investigational agents while participating in this study. * Psychiatric illness/social situations that could limit compliance with study requirements. * Pregnant or breast feeding. * Fami…