Metformin as RenoProtector of Progressive Kidney Disease

Exclusion criteria

• ✕. Illiteracy: patients not knowing how to read or write
• ✕. Patients not able to communicate in Dutch or French
• ✕. Patients with mental deterioration, incapable to give informed consent and to understand the safety instructions of the study (at the discretion of the treating nephrologist)
• ✕. Patients with one of the following clinical problems:
• ✕. Patients showing elevated blood lactate level(s) at the time of recruitment (i.e. a confirmed lactate level ≥ 2.5 mmol/L at baseline and a confirmed lactate level ≥ 2.5 mmol/L after 4 weeks (±1 week)).
• ✕. Patients showing a confirmed (after 3 months) serum bicarbonate level \< 22 mmol/L (or \< 20 mmol/L if delay of more than 1 hour between sampling and determination)
• ✕. Hypersensitivity to metformin or to any of the excipients listed in section 6.1 of the Glucophage SR SmPC (see Attachment A5 Glucophage SR SmPC)
• ✕. One of the following diseases during the previous 6 months: myocardial infarction, shock, acute problems of decompensated heart failure or respiratory failure.