Active — Not RecruitingNot Applicable

PErsonalized Genomics for Prenatal Abnormalities Screening USing Maternal Blood

Canada7,849 participantsStarted 2020-01-13

Plain-language summary

This project aims to provide high- quality evidence to inform decisions by health care organisations about using first-tier non-invasive prenatal screening (NIPS) to replace traditional screening tests for trisomy 21, and potentially to screen for other fetal chromosome anomalies. We will compare the current screening approach of second-tier NIPS with the use of first-tier NIPS in a large cohort of pregnant women.

Who can participate

Age range19 Years

SexFEMALE

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Inclusion Criteria: * Pregnant women 19 years or older wanting prenatal screening * 10-13+6 wks determined by dating ultrasound or last menstrual period. * Not intending to pursue self pay NIPT Exclusion Criteria: * Known fetal anomaly at the time of recruitment * Multiple gestation * Known twin demise * Planned CVS or amnio for known genetic condition.

What they're measuring

Gestational age at diagnosis

Timeframe: Up to 24 weeks of gestational age

Trial details

NCT IDNCT03831256

SponsorCHU de Quebec-Universite Laval

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-12-31

View on ClinicalTrials.gov More Prenatal Disorder trials