Development of a Point of Care System for Automated Coma Prognosis

Inclusion Criteria: * Patients (≥ 18 years of age) primarily admitted to the Intensive Care Units, Neurological Step Down Unit, or Coronary Care Unit at Hamilton General Hospital who are in coma with Glasgow Coma Scale (GCS) score of 3-8, or; * Patients (≥ 18 years of age) who have other disorders of consciousness, primarily Minimally Conscious State (MCS) or Unresponsive Wakefulness Syndrome (UWS; also known as vegetative state). Exclusion Criteria: * Severe liver failure (i.e., Child-Pugh Class C) * Severe renal failure (i.e., Urea ≥ 40) * Previous open-head injury * Known primary and secondary central nervous system malignancy * Known hearing impairment * Previous intracranial pathology requiring neurosurgical interventions in the past 72 hours * Anyone who is deemed medically unsuitable for this study by the attending intensivists Healthy Controls: Inclusion: * ≥ 18 years of age * no visual, language, learning, or hearing problems * no history of neurological or psychiatric disorder * not currently taking any medications that act on the central nervous system, such as antidepressants, anxiolytics, or anti-epileptics Exclusion: (During the COVID-19 pandemic only) * ≥ 60 years of age * have a weakened immune system * have one or more of the COVID-19 high risk medical conditions, according to the government of Canada website: https://www.canada.ca/en/public-health/services/publications/diseases-conditions/people-high-risk-for-severe-illness-covid-19.html.