CompletedNot Applicable

Auburn University Research on Olive Oil for Alzheimer's Disease (AU-ROOAD)

United States25 participantsStarted 2019-05-07

Plain-language summary

Until now there is no medical treatment and/or intervention that can slow, stop or reverse the underlying neurodegenerative of Alzheimer's disease (AD). The goal of this study is to demonstrate "Oleocanthal rich-extra-virgin olive oil (EVOO) consumption stops or delay mild cognitive impairment conversion to AD by restoring the blood-brain barrier (BBB) function in humans". Specific Aims: 1. Evaluate effect of EVOO on the brain function by functional MRI (fMRI) imaging, and BBB function by dynamic contrast-enhanced MRI (DCE-MRI). 2. Evaluate effect of EVOO on cognitive function and on selected biomarkers

Who can participate

Age range55 Years – 75 Years

SexALL

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Inclusion criteria

✓. Mini-Mental State Exam (MMSE) scores between 18-30 (based on education level
✓. memory complaint, have objective memory loss measured by education adjusted scores on Wechsler Memory Scale Logical Memory VI
✓. Clinical Dementia Rating (CDR) score 0.5.

Exclusion criteria

✕. Subjects with contradictions for MRI include: the presence of metal or electronic devices such as metallic joint prostheses, artificial heart valves, an implantable heart defibrillator, a pacemaker, metal clips, cochlear implants, a bullet, shrapnel or any other type of metal fragment; breathing problems or disorders, claustrophobia, inner ear disorders, vertigo or dizziness, tattoos or permanent makeup that contains metal, and body piercing jewelry that cannot be removed.
✕. Subjects will be excluded if they are smokers
✕. Subjects who have have clinically important medical or neuropsychiatric comorbidity.
✕. Subjects who have renal problems or are allergic to the MRI contrast agent.

What they're measuring

Effect of olive oil on the BBB intactness

Timeframe: 6 months

Effect of olive oil on the brain activity

Timeframe: 6 months

Trial details

NCT IDNCT03824197

SponsorAuburn University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2020-12-31

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