ABCSG C08-Exercise II: Trial of Endurance Exercise Following Adjuvant Chemotherapy for Colorectal Cancer

Inclusion Criteria: * completely resected, histologically confirmed adenocarcinoma of the colon or rectum * patients, who have completed adjuvant chemotherapy 4-16 weeks prior to randomization * Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 * Age ≥18 years * adequate hematologic functions \<=28d prior to randomization * able to perform endurance exercise according to protocol * ability to perform ergometry in order to assess physical capability at the discretion of the investigator * signed informed consent prior to randomization Exclusion Criteria: * significant comorbid conditions precluding participation in a physical activity program (investigators decision) * disabled patients unable to participate in the physical activity program * Regular (3-times a week) vigorous physical activity of \>150 minutes (type of physical activity: bicycling, cross walking (cross trainer), jogging, walking at a brisk pace, nordic walking, cross country skiing) within the last year before diagnosis of colorectal cancer * patients unwilling to complete endurance exercise or complete all questionnaires related to the study * past or current history of other malignant neoplasms other than colorectal cancer in the last 5 years except basal cell carcinoma of the skin and/or in situ carcinoma of the cervix * clinically significant cardiovascular disease * left bundle branch block * current study with chemotherapy or radiation * current pregnancy or plans to become pregna…