Cisplatin Disposition and Kidney Injury

Inclusion Criteria: * Male or female patient prescribed cisplatin at a dose of \>25mg/m\^2 * Age 18-80 years * Hemoglobin \>/=9 g/dl * No consumption of grapefruit juice or alcohol within 7 days * No history of alcohol consumption of \>14 drinks/week * No history of organ transplantation or kidney dialysis * Willingness to comply with study * Not pregnant or lactating * No changes in chronic medications within 2 weeks * Estimated glomerular filtration rate (eGFR) \> 60 ml/min\^2 * Normal liver function (ALT and AST \<2x ULN) Exclusion Criteria: * Diagnosis of kidney cancer * Previous exposure to platinum-based chemotherapy with the exception of one previous dose as part of the current course * Herbal supplement use beyond marijuana * Exposure to other known nephrotoxins (including contrast agents) within the previous 2 weeks * Severe gastrointestinal disease with fluid losses * Diagnosis of a rapidly progressive glomerulonephritis * Allergy or contraindication to 5-HT3 Antagonists