The objective of this study is to evaluate the effect of Centella asiatica on hydration status of lower leg skin of DM type 2 patients by measuring SRRC and Skin Capacitance in correlation with AGEs CML, inflammation marker IL-1α, and oxidative stress SOD in stratum corneum.
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Change in Skin Capacitance
Timeframe: 1 month (evaluated every 2 weeks)
Change in SOD
Timeframe: 1 month (evaluated every 2 weeks)
Change in IL-1α
Timeframe: 1 month (evaluated every 2 weeks)
Change in AGEs CML
Timeframe: 1 month (evaluated every 2 week)
Change in SRRC
Timeframe: 1 month (evaluated every 2 week)