Turner syndrome (TS) is a rare chromosomal disorder characterized by partial or complete loss of one of the X chromosomes that affects about one in every 2000 female babies born. These young patients described difficulties making friends, understanding others' emotions and intentions, and controlling their own emotions. Difficulties in these domains could led to social withdrawal, to reduced social skills and could have a significant impact on self esteem and mental health as well as on long-term academic and social functioning in affected individuals. The purpose of this project is to identify functional and dysfunctional cognitive and socio-cognitive abilities in these young patients which could account social difficulties described by some of them and their family. To this end, 35 girls with TS and 35 girls with isolated growth hormone deficiency and normal cerebral MRI will be recruited. Subjects will be 7 to 16 years and 11 months of age. Socio-cognitive and cognitive functions will be assessed with neuropsychological and experimental tasks. Questionnaires completed by patient, parents or teacher, will evaluate social and behavioral functioning.
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Wechsler Intelligence Scale for Children (WISC-V)
Timeframe: 3 months
Cognitive theory of mind first order
Timeframe: 3 months
Cognitive theory of mind second order
Timeframe: 3 months
Cognitive theory of mind advanced
Timeframe: 3 months
Cognitive theory of mind : humor
Timeframe: 3 months
Affective theory of mind : faux pas
Timeframe: 3 months
Affective theory of mind : first order
Timeframe: 3 months
Affective theory of mind : second order
Timeframe: 3 months
Affective theory of mind : emotional inference
Timeframe: 3 months
Emotional valence recognition : valence
Timeframe: 3 months
Facial emotion recogniton
Timeframe: 3 months
Vocal emotion recognition
Timeframe: 3 months
Emotional regulation
Timeframe: 3 months
Alexithymia
Timeframe: 3 months
Empathy
Timeframe: 3 months
Oral Language comprehension abilities 1
Timeframe: 3 months
Oral Language comprehension abilities 2
Timeframe: 3 months
Visual and visual-spatial abilities:1
Timeframe: 3 months
Visual and visual-spatial abilities:2
Timeframe: 3 months
Visual and visual-spatial abilities:3
Timeframe: 3 months
Executive abilities-Verbal Working memory 1
Timeframe: 3 months
Executive abilities-Visuo-Spatial Working memory 2
Timeframe: 3 months
Executive abilities-Inhibition 1
Timeframe: 3 months
Executive abilities-Inhibition 2
Timeframe: 3 months
Executive abilities-Inhibition 3
Timeframe: 3 months
Executive abilities-Cognitive Flexibility 1
Timeframe: 3 months
Executive abilities-Cognitive Flexibility 2
Timeframe: 3 months
Executive abilities-Cognitive Flexibility 3
Timeframe: 3 months
Executive abilities-Higher-order executive functions 1
Timeframe: 3 months
Executive abilities-Higher-order executive functions 2
Timeframe: 3 months
Executive abilities in daily life
Timeframe: 3 months
Self Esteem
Timeframe: 3 months
Depression inventory
Timeframe: 3 months
Anxiety inventory
Timeframe: 3 months
Social desirability
Timeframe: 3 months
social adjustment 1
Timeframe: 3 months
social adjustment 2
Timeframe: 3 months
behavioral adjustment
Timeframe: 3 months