RecruitingNot Applicable

Neuropsychological Assessment of Children and Adolescents With Turner Syndrome

France70 participantsStarted 2019-09-05

Plain-language summary

Turner syndrome (TS) is a rare chromosomal disorder characterized by partial or complete loss of one of the X chromosomes that affects about one in every 2000 female babies born. These young patients described difficulties making friends, understanding others' emotions and intentions, and controlling their own emotions. Difficulties in these domains could led to social withdrawal, to reduced social skills and could have a significant impact on self esteem and mental health as well as on long-term academic and social functioning in affected individuals. The purpose of this project is to identify functional and dysfunctional cognitive and socio-cognitive abilities in these young patients which could account social difficulties described by some of them and their family. To this end, 35 girls with TS and 35 girls with isolated growth hormone deficiency and normal cerebral MRI will be recruited. Subjects will be 7 to 16 years and 11 months of age. Socio-cognitive and cognitive functions will be assessed with neuropsychological and experimental tasks. Questionnaires completed by patient, parents or teacher, will evaluate social and behavioral functioning.

Who can participate

Age range

7 Years – 16 Years

Sex

FEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

INCLUSION CRITERIA Turner syndrome group : * girls with diagnosed Turner syndrome. Isolated GHD group : * girls with diagnosed isolated growth hormone deficiency All participants : * age between 7 years to 16 years and 11 months. * informed consent signed by the participant and her parents (or her legal representatives) * being registered in the national social security system EXCLUSION CRITERIA : Turner syndrome group : * patients with chronic pathology other than Turner syndrome. * karyotype : part of a Y chromosome and r(X) cases. * medical treatment other than those usually prescribed in patients with Turner syndrome. Isolated GHD group : * patients with chronic pathology other than isolated growth hormone deficiency. * medical treatment other than those usually prescribed in patients with isolated growth hormone deficiency. All participants : * diagnosed intellectual disability (IQ\<70) or intellectual giftedness * history of acquired brain injury * sensory disturbances (auditory or visual) incompatible with the achievement of neuropsychological tasks. * insufficient French language proficiency

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Wechsler Intelligence Scale for Children (WISC-V)

Timeframe: 3 months

Cognitive theory of mind first order

Timeframe: 3 months

Cognitive theory of mind second order

Timeframe: 3 months

Cognitive theory of mind advanced

Timeframe: 3 months

Cognitive theory of mind : humor

Timeframe: 3 months

Affective theory of mind : faux pas

Timeframe: 3 months

Affective theory of mind : first order

Timeframe: 3 months

Affective theory of mind : second order

Timeframe: 3 months

Trial details

NCT IDNCT03812913

SponsorUniversity Hospital, Angers

Sponsor typeOTHER_GOV

Study typeOBSERVATIONAL

Primary completion2025-12-05

Contact for this trial

Régis Coutant, MD PhD

33(02)41-35-56-55 ReCoutant@chu-angers.fr

View on ClinicalTrials.gov More Turner Syndrome trials

Plain-language summary

Who can participate

Age range

7 Years – 16 Years

Sex

FEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Wechsler Intelligence Scale for Children (WISC-V)

Timeframe: 3 months

Cognitive theory of mind first order

Timeframe: 3 months

Cognitive theory of mind second order

Timeframe: 3 months

Cognitive theory of mind advanced

Timeframe: 3 months

Cognitive theory of mind : humor

Timeframe: 3 months

Affective theory of mind : faux pas

Timeframe: 3 months

Affective theory of mind : first order

Timeframe: 3 months

Affective theory of mind : second order

Timeframe: 3 months