Randomized Study of Stereotactic Body Radiation Therapy (SBRT) in Patients With Oligoprogressive Metastatic Cancers of the Breast and Lung

Inclusion criteria

• ✓. At least a 20% increase in the sum of the longest diameter (LD) of the lesion, taking as reference the smallest sum LD recorded since the last imaging OR
• ✓. The appearance of one or more new lesions OR
• ✓. New/malignant FDG uptake in the absence of other indications of progressive disease or an anatomically stable lesion OR
• ✓. \>/= 5mm increase in the diameter sum of the lesion
• ✓. \>30% increase in 18F-FDG SUV peak, with \>0.8 SUV units increase in tumor SUV from the baseline scan in pattern typical of tumor and not of infection/treatment effect OR
• ✓. Visible increase in the extent of 18F-FDG tumor uptake OR
• ✓. New 18F-FDG avid lesions typical of cancer (including new bone lesion) and not related to treatment effect and/or infection
• ✓. If the clinical scenario deem that other forms of local therapy may be more suitable for the metastatic disease, such as surgical resection and interventional radiology-guided ablation, patients would be able to undergo other forms of local therapy with discussion with the PI.