UnknownNot Applicable

Heart Failure After Heart Transplantation Due to Chronic Rejection

Sweden100 participantsStarted 2019-01

Plain-language summary

This study will investigate the prevalence of allograft vasculopathy and unexplained graft dysfunction during long-term follow-up after heart transplantation. Risk factors as well diagnostic approaches will be investigated.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Heart transplant performed more than 10 years and less than 21 years ago * Scheduled yearly post-transplant control * Signed informed consent Exclusion Criteria: * Estimated GFR \< 30 mL/min/1,73m2 * Radiographic contrast allergy * Severe asthma or COLD with FEV1 \< 50% * Second or third degree AV block * Pregnancy * In the Investigator's opinion, the patient has a clinically significant disease that could be adversely affected by study participation

What they're measuring

Degree of stenosis in coronary arteries

Timeframe: 4 hours

Restrictive allograft hemodynamics

Timeframe: 2 hours

Functional assessment of the microvasculature

Timeframe: 2 hours

Degree of myocardial fibrosis

Timeframe: 4 hours

Trial details

NCT IDNCT03808324

SponsorSahlgrenska University Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2021-01

View on ClinicalTrials.gov More Cardiac Allograft Vasculopathy trials