The purpose of this study is to determine the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of different modes of (S) ketamine administration in healthy participants.
Age range
18 Years – 50 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Part 1: Change from Baseline in Clinician-Administered Dissociative States Scale (CADSS) Total Score
Timeframe: Baseline up to Day 1
Part 2: Change from Baseline in CADSS Total Score
Timeframe: Baseline up to Day 1
Part 1: Number of Participants with Vital Sign Abnormalities
Timeframe: Up to Day 2
Part 2: Number of Participants with Vital Sign Abnormalities
Timeframe: Up to Day 2
Plasma Concentrations of (S)-ketamine
Timeframe: Part 1: Predose, 1, 3, 5, 10, 15, 30, 40 min, 1, 1.5, 2, 3, 4, 6, 8, 12, and 24 hour postdose; Part 2: predose, 15, 30 min, 1, 1.6, 2, 3, 3.5, 4, 6, 8, 10, 12, and 24 hours postdose
Plasma Concentrations of Nor(S)-ketamine
Timeframe: Part 1: Predose, 1, 3, 5, 10, 15, 30, 40 min, 1, 1.5, 2, 3, 4, 6, 8, 12 and 24 hour postdose; Part 2: predose, 15, 30 min, 1, 1.6, 2, 3, 3.5, 4, 6, 8, 10, 12 and 24 hours postdose
Part 1: Change from Baseline in Electroencephalogram (EEG) Power
Timeframe: Predose (Baseline) and 2.25 hours postdose
Part 2: Change from Baseline in EEG Power
Timeframe: Predose (Baseline) and 3.25 hours postdose
Part 1: Change from Baseline in Continuous Paired Associate Learning Test (cPALT) Score
Timeframe: Baseline up to Day 1
Part 2: Change from Baseline in cPALT Score
Timeframe: Baseline up to Day 1