Effectiveness and Safety of Tofacitinib in Patients With Extensive and Recalcitrant Alopecia Areata

Inclusion Criteria: * Thai volunteers age between 18 and 60 years old. * Volunteers must be patients who suffer from severe AA more than 50% of the entire scalp. * Volunteers must be patients who are able to complete the monthly treatment at least in the first 6 months. Exclusion Criteria: * Patients who suffer from other hair diseases such as: Telogen effluvium, Trichotillomania, Tinea capitis * Patients who have other diseases that can have an impact on hair loss or temporary hair loss condition with in 6 months prior to the study such as: thyroid problems, liver disease, malnutrition, hearth disease, neurological disease, gastrointestinal disorders, sexually transmitted disease, cancer, psychiatric disease. * Patients with AA who received treatment with either steroid, Anthralin or DPCP application within 1 month before the selection or patients who had oral or injection from steroid or other medication for hair loss treatment within 3 months before the selection. * Woman with pregnancy