Efficacy and Safety of Ucha-Shinki-Hwan on Korean Patients With Cold Hypersensitivity in the Hands and Feet-Double Blinded, Randomized, Multicenter, Placebo Controlled Clinical Trial

Inclusion Criteria: * Female subjects aged 19 to 59 years have a complaint of CHHF. * Patients must include at least one or more of the following symptoms: * Those who have the symptoms of CHH in normal temperature which most individuals feel no cold; * Those who have the symptoms of extremely cold hands in cold temperature exposure; * Those who are on the return to a warmer environment, the symptoms of cold hands is not completely rewarmed; * Those who have 4 cm or greater of VAS CHH score; * A thermal differences between the palm (PC8) and the upper arm (LU4) may be higher than 0.3℃; * Those who can comply with all study-related procedures, medications, and evaluations; * Given a written informed consent form. Exclusion Criteria: * Patients with calcium antagonists or beta-blockers with the purpose of treating CHH; * Those who have one or more finger gangrene or ulceration; * Those who are diagnosed by hypothyroidism or currently medicated to thyroid drugs; * Those who are diagnosed by autoimmune disease or have a positive ANA test result; * Those who are diagnosed by carpal tunnel syndrome or have a positive Tinel and Phalen's tests; * Those who are diagnosed with cervical disc herniation or (malignant) tumor disease; * Those who are diagnosed with diabetes; * Those who are currently medicated to drugs that may affect to CHH symptoms, such as anticoagulants etc; * Those who have moderate level of liver dysfunction (each of AST, ALT greater than 100 IU/L) or kidney dysfu…