A Study to Learn More About the Relationship Between the Development of a Gap in the Upper Lip (Cleft Lip) or in the Roof of the Mouth (Cleft Palate) in Newborns and the Use of Glucocorticoids by the Mother During Pregnancy: a Meta-analysis

Inclusion Criteria: * Population: Pregnant women * Intervention: Any glucocorticoid or corticosteroid or steroids use irrespective of mode of administration * Comparator: Any/none * Outcomes: Incidence/ risk of cleft lip/palate in infants * Study Design: * Meta-analysis and systematic literature reviews * Observational studies (such as cohort study, case-control study, registries data) * Clinical trials - Phase IIb, III, and IV * Conference abstracts/posters * Time period: No time period restriction * Geography: No geography restriction Exclusion Criteria: * Population: Nonpregnant women * Intervention: Drugs other than glucocorticoid or corticosteroid or steroid * Outcomes: Incidence/ risk of cleft lip/palate in infants * Study Design: * Animal Study * In vitro studies * Editorial, letters, comment * Clinical trials - Phase I or preclinical * Case reports, case series * Reviews * Studies focusing on: * Diagnosis and surgical procedure for cleft repair * Impact of Increased internal corticosteroids due to stress * The relationship between genetic mutations and cleft patients * Adverse events for other drugs * Safety profiles of glucocorticoid or corticosteroid