CompletedNot Applicable

Bone Metabolic Activity in the Patellofemoral Joint in Patients With Unilateral PFP

Denmark27 participantsStarted 2019-01-02

Plain-language summary

This study aims to examine whether individuals with unilateral patellofemoral pain (PFP) have increased subchondral bone remodelling and thus increased 18F Sodium Fluoride (18F-NaF) uptake in the painful knee compared to the opposite knee measured by simultaneous positron emission tomography and computed tomography (PET/CT) and to examine whether the increased uptake is associated with pain intensity, with patient-reported function and with pain localization. Furthermore we aim to investigate the effect of an acute patellofemoral loading bout on the bone remodelling.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * A clinical diagnosis of PFP in at least one knee confirmed by an experienced sports medicine doctor. * Visual analogue score rating of pain during activities of daily living during the previous week at a minimum of 3 on a 10 cm scale. * Insidious onset of symptoms unrelated to trauma and persistent for at least 4 weeks. * Pain in the anterior knee associated with at least 3 of the following: * During or after activity * Prolonged sitting * Stair ascent or descent * Squatting Exclusion Criteria: * Meniscal or other intra-articular injury * Cruciate or collateral ligament laxity or tenderness * Patellar tendon, iliotibial band, or pes anserine tenderness * Osgood-Schlatter or Sinding-Larsen-Johansson syndrome * History of recurrent patellar subluxation or dislocation * History of surgery to the knee joint * History of head injury or vestibular disorder within the last 6 months * Pregnancy * Breastfeeding

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

18F NaF-PET/CT uptake

Timeframe: Cross sectional assessment at baseline, i.e., before the loading programme.

Trial details

NCT IDNCT03784235

SponsorUniversity Hospital Bispebjerg and Frederiksberg

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2021-12-01

View on ClinicalTrials.gov More Patellofemoral Pain Syndrome trials