CompletedNot Applicable

Bone Metabolic Activity in the Patellofemoral Joint in Patients With Unilateral PFP

Denmark27 participantsStarted 2019-01-02

Plain-language summary

This study aims to examine whether individuals with unilateral patellofemoral pain (PFP) have increased subchondral bone remodelling and thus increased 18F Sodium Fluoride (18F-NaF) uptake in the painful knee compared to the opposite knee measured by simultaneous positron emission tomography and computed tomography (PET/CT) and to examine whether the increased uptake is associated with pain intensity, with patient-reported function and with pain localization. Furthermore we aim to investigate the effect of an acute patellofemoral loading bout on the bone remodelling.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * A clinical diagnosis of PFP in at least one knee confirmed by an experienced sports medicine doctor. * Visual analogue score rating of pain during activities of daily living during the previous week at a minimum of 3 on a 10 cm scale. * Insidious onset of symptoms unrelated to trauma and persistent for at least 4 weeks. * Pain in the anterior knee associated with at least 3 of the following: * During or after activity * Prolonged sitting * Stair ascent or descent * Squatting Exclusion Criteria: * Meniscal or other intra-articular injury * Cruciate or collateral ligament laxity or tenderness * Patellar tendon, iliotibial band, or pes anserine tenderness * Osgood-Schlatter or Sinding-Larsen-Johansson syndrome * History of recurrent patellar subluxation or dislocation * History of surgery to the knee joint * History of head injury or vestibular disorder within the last 6 months * Pregnancy * Breastfeeding

What they're measuring

18F NaF-PET/CT uptake

Timeframe: Cross sectional assessment at baseline, i.e., before the loading programme.

Trial details

NCT IDNCT03784235

SponsorUniversity Hospital Bispebjerg and Frederiksberg

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2021-12-01