Treatment Response to Xiaflex for Men With Peyronie's Disease

Inclusion Criteria: * Age ≥18 years * Able to provide informed consent * A stable relationship for ≥3 months * PD symptoms with evidence of stable disease as determined by the investigator * Penile curvature deformity of \>30° to \<90° * Has not had previous surgery for PD * Has not had previous therapy with Xiaflex for PD Exclusion Criteria: * Ventral plaque * Active phase PD * Actively on anticoagulation during time frame of injections * Aspirin 81mg will be eligible for therapy * Hour glass deformity * Previous allergic reaction to Xiaflex * Unwilling to participate * Medically unfit for sexual intercourse as deemed by the principal investigator * Patients scheduled to undergo an elective medical procedure during the investigation timeframe that will interfere with Xiaflex injection cycles as deemed by the PI