CompletedNot Applicable

Dyspnea Assessment in Hemodialysis Patients

Canada7 participantsStarted 2019-03-29

Plain-language summary

Shortness of breath is very common among patients on dialysis for kidney failure; however, its causes are often not understood. This study will explore the lungs and the heart of these patients to determine the causes of shortness of breath. The amount of salt in the body tissues, which tends to accumulate in dialysis patients and can also cause shortness of breath, will also be measured. Machines that exploit magnetic resonance, ultrasound and x-rays to take images of the body interior will be employed; in addition, breathing tests, questionnaires and blood tests will also be used. 20 patients on dialysis will be recruited and have two visits: one at the beginning of the study and one year later to observe any changes in the lungs, heart and salt accumulation over time.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age equal to or greater than 18 years. * Dialysis vintage equal to or greater than 3 months. Exclusion Criteria * Smoking history of more than 10 packs/year. * Active tobacco and/or cannabis smoking. * Diagnosed chronic pulmonary disease. * Severe heart failure (NYHA class IV) * Active infection (including tuberculosis) or malignancy. * Pregnancy. * Inability to give consent or understand written information. * Peripheral oxygen saturation (by pulse oxymetry) dropping below 80% when performing a 12-seconds breathhold. * Inability to perform spirometry or plethysmography maneuvers. * Inability to tolerate MRI due to patient size and/or known history of claustrophobia. * Subject has an implanted mechanically, electrically or magnetically activated device or any metal in their body which cannot be removed, including but not limited to pacemakers, neurostimulators, biostimulators, implanted insulin pumps, aneurysm clips, bioprosthesis, artificial limb, metallic fragment or foreign body, shunt, surgical staples (including clips or metallic sutures and/or ear implants.).

What they're measuring

Baseline Modified Medical Research Council scale score.

Timeframe: Baseline

Baseline University of California, San Diego Shortness of Breath Questionnaire score.

Timeframe: Baseline

Baseline pulmonary artery diameter.

Timeframe: Baseline

Baseline lung total blood vessel volume.

Timeframe: Baseline

Baseline lung total airway count.

Timeframe: Baseline

Baseline lung low attenuation area.

Timeframe: Baseline

Baseline lung water content.

Timeframe: Baseline

Baseline soft tissue sodium content.

Timeframe: Baseline

Trial details

NCT IDNCT03773991

SponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2020-02-25

View on ClinicalTrials.gov More Dyspnea; Uremic trials

Plain-language summary

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Baseline Modified Medical Research Council scale score.

Timeframe: Baseline

Baseline University of California, San Diego Shortness of Breath Questionnaire score.

Timeframe: Baseline

Baseline pulmonary artery diameter.

Timeframe: Baseline

Baseline lung total blood vessel volume.

Timeframe: Baseline

Baseline lung total airway count.

Timeframe: Baseline

Baseline lung low attenuation area.

Timeframe: Baseline

Baseline lung water content.

Timeframe: Baseline

Baseline soft tissue sodium content.

Timeframe: Baseline