UnknownNot Applicable

MRI Maker of Perioperative Neurocognitive Disorder

China100 participantsStarted 2018-12-12

Plain-language summary

Periperative neurocognitive disorder(PND) is consistently associated with increased morbidity and mortality, but its mechanisms remain unclear. Moreover, valid biomarkers for the prediction or diagnosis of the development of delayed neurocognitive recovery in aged patients have not been identified so far. The purpose of this study is trying to find the functional MRI marker of PND.

Who can participate

Age range60 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age ≥ 60 years * Spoke proficient Chinese * Selected to lower limb osteopathic surgery * Informed consent signed by the patient * Underwent general anesthesia Exclusion Criteria: * Existing cerebral disease, or have a history of neurological and psychiatric diseases including AD, stroke, and psychosis * Existing cognitive impairment as evidenced by Mini-Mental State Examination scores below 24 * Several audition or vision disorder * With standard contraindications to MRI examinations * Unwillingness to comply with the protocol or procedures.

What they're measuring

MRI markers of PND before 7th day after surgery

Timeframe: From the day before surgery to the 7th day after surgery

Trial details

NCT IDNCT03773627

SponsorRenJi Hospital

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2019-12-30

Contact for this trial

Diansan Su, Dr.

+862168383702 diansansu@yahoo.com

View on ClinicalTrials.gov More Necrosis of Femoral Head trials