CompletedNot Applicable

Sevoflurane vs Propofol Effect on Endothelial Damage Markers After Knee Ligament Surgery.

Chile16 participantsStarted 2018-12-20

Plain-language summary

Endothelial damage has been reported after ischemia-reperfusion events. This can be characterized by measurements of glycocalyx and endothelial components that are released to blood after the insult. Sevoflurane and inhaled anesthetic commonly used for surgery have shown protective endothelial effects in animal and in-vitro models. Knee-ligament surgery with the use of a femoral tourniquet generates a transient ischemia-reperfusion (IR) state after the tourniquet is released. This research aims to compare the effect of sevoflurane and propofol in the release of glycocalyx and endothelial biomarkers after IR in this surgical scenario.

Who can participate

Age range18 Years – 60 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * American Society of Anesthesiologists Classification (ASA Class) I and II * Elective knee ligament surgery * Use of a femoral tourniquet Exclusion Criteria: * Allergies to egg or soya * Previous history of critical events during surgery and perioperative period * Patients at risk of hyperthermia malignant * Patients with 3 or more predictor of difficult airway management

What they're measuring

Syndecan-1 levels

Timeframe: At the moment of IV placement (baseline values), during surgery before of tourniquet release (TR), 10, 60 and 90 min minutes after TR

Trial details

NCT IDNCT03772054

SponsorUniversity of Chile

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2019-12-11

View on ClinicalTrials.gov More Ischemia Reperfusion Injury trials