UnknownNot Applicable

Continuous Positive Pressure Versus Bi-level in Overlap Syndrome

70 participantsStarted 2019-01-01

Plain-language summary

Continuous positive airway pressure (CPAP) became the established treatment for overlap syndrome (OS). It has been showed that the survival benefits of CPAP favored hypercapnic patients. When considering hypercapnic stable COPD patients, survival benefits occurred when the use of bi- level ventilation therapy was targeted to significantly reduce hypercapnia. This highlights the relevance of hypercapnia and hypoventilation correction. Thus, the purpose of this study is to compare the use of CPAP to Bi-level ventilation in hypercapnic OS patients, since the later may correct not only the airway patency but also increase the magnitude of each breath.

Who can participate

Age range40 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * COPD (FEV1/FVC \< 70 (post-BD) and history of smoking - 10 PPY) * FEV1\< 80% and COPD symptoms * AHI ≥ 15 events/hour Exclusion Criteria: * Persistent hypercapnic respiratory failure with acidosis (defined as pH \<7.30 after bronchodilators) * Hypoxia requiring long term oxygen therapy * BMI \> 35 kg/m2 * Previously-initiated long term non-invasive positive pressure ventilation * Other lung disease resulting in respiratory symptoms * Age \<40 years * Pregnancy * Malignant comorbidities * Patients undergoing renal replacement therapy * Restrictive lung disease causing hypercapnia * Severe heart failure, unstable angina and severe arrhythmias * Inability to comply with the protocol

What they're measuring

diurnal hypercapnia (pCO2 <= 45 mmH2O )

Timeframe: 1 year

nocturnal oxygen desaturation correction

Timeframe: 1 year

Trial details

NCT IDNCT03766542

SponsorHospital Sao Joao

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2020-07-01