CompletedEarly Phase 1

Postoperative Aspirin and Ankle Fracture Healing

United States500 participantsStarted 2019-06-12

Plain-language summary

This study aims to identify if postoperative aspirin use leads to a delay in fracture healing. NSAIDs have long been avoided in the management of fractures, due to the belief that they may impair fracture healing. As aspirin is frequently prescribed for long-term management of various medical conditions, it is worth understanding if continuing to take aspirin during the process of fracture healing has a clinically significant effect on the rate of fracture healing.

Who can participate

Age range18 Years – 110 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Over 18 years of age * healthy enough for orthopedic surgery * slated to undergo surgical repair of ankle fracture at UAB * able to give consent All ankle fractures (lateral malleolus, medial malleolus, bimalleolar, trimalleolar, and proximal fibula) will be included in this study. Exclusion Criteria: * Under 18 years of age * inability to give consent * Pilon fractures * Multiple traumatic fractures * Known history of aspirin allergy * History of severe reaction to aspirin * History of bleeding disorder * Other clear contraindication to being prescribed aspirin * Taking blood-thinning medications (heparin, apixaban, etc) * Taking aspirin prior to the start of the study

What they're measuring

Ankle Fracture Healing

Timeframe: 0 - 12 months following surgery

Trial details

NCT IDNCT03765619

SponsorUniversity of Alabama at Birmingham

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2019-11-26

View on ClinicalTrials.gov More Ankle Fractures trials