WithdrawnNot Applicable

The Effect of Water Intake on Glucose Regulation

Stopped: Study did not get funded

0Started 2019-02-11

Plain-language summary

There is a growing body of evidence suggesting low water intake and elevated levels of the hormone vasopressin exacerbate glucose regulation. This project will examine the physiological mechanism by which low water intake impairs glucose homeostasis. In the current proposal we aim to: 1) quantify the degree of glucose impairment as a response to elevated vasopressin due to low water intake and 2) identify the physiological mechanism by which elevated vasopressin, as a response to low water intake, impairs glucose regulation

Who can participate

Age range30 Years – 55 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: BMI 27.5-35 Exclusion Criteria: * BMI \<27.5 or \>35 * high physical activity * diabetes * impaired liver or kidney function * cardiovascular disease * weight change of more than 3 kg in the past month * pregnancy * previous surgery on digestive tract (except appendectomy) * fluid balance will be exclusionary such as * serotonin re-uptake inhibitors.

What they're measuring

amount of glucose metabolized M

Timeframe: 220-240 min & 340-360 min of the protocol

metabolic clearance rate for insulin

Timeframe: 220-240 min & 340-360 min of the protocol

quantity of glucose metabolized per unit plasma insulin concentration

Timeframe: 220-240 min & 340-360 min of the protocol

Rate of glucose appearance & disappearance

Timeframe: 220-240 min & 340-360 min of the protocol

Trial details

NCT IDNCT03765008

SponsorArizona State University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2019-04-03

View on ClinicalTrials.gov More Glucose Metabolism Disorders trials