Scaling and Root Planing (SRP) With and Without Minocycline HCl Microspheres, 1 mg

Inclusion Criteria: * Male and Female * At least 18 years of age * ADA Class III-IV Chronic Periodontitis * Scaling and Root Planing (SRP) or localized SRP * A minimum of eight sites with pockets ≥5mm with bleeding on probing (any quadrant) Exclusion Criteria: * Unable to comply with study protocol * Completed treatment of Scaling and Root Planing (SRP) and/or localized SRP within the last 6 months * Cigarette use within the last year * ≥2 weeks of antibiotic use in the past three months. Or antibiotic use in the last six weeks. * Pregnant, planning to become pregnant, or unsure of pregnancy status (self- reported) * Diagnosed cardiac conditions (cardiovascular disease (CVD) or atherosclerotic vascular disease (ASVD) including coronary heart disease, cerebrovascular disease, and peripheral artery disease, myocardial infarction, stroke, stable or unstable angina, transient ischemic attack, or coronary or other arterial revascularization * Have any uncontrolled medical condition or immunocompromised that may impact the study (uncontrolled diabetes HbA1c \> 7, HIV, etc.) * Tetracycline allergy * Any medication that may impact periodontal conditions (Phenytoin, calcium antagonists, cyclosporin, warfarin, or NSAIDS)