WithdrawnNot Applicable

The Effect of Remote Ischemic Preconditioning on Ischemia/Reperfusion Injury in a Liver Transplant Recipient

Stopped: Large sample size

0Started 2020-04

Plain-language summary

Ischemia and reperfusion injury is unavoidable during a liver transplantation. Remote ischemic preconditioning, a safe and feasible method, has previously been shown to reduce ischemia and reperfusion injury. In the transplantation setting, focus of remote ischemic preconditioning has been on the donor. However, preconditioning of the recipient may be a better approach due to the mechanisms by which ischemic preconditioning protects against ischemia and reperfusion injury. The aim of this randomised, double-blinded clinical trial is to biochemically assess the liver function after application of remote ischemic preconditioning on the recipient.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients undergoing liver transplantation * Patients aged 18 or above * Patients who have given an informed consent Exclusion Criteria: * Patients undergoing re-transplantation. * Patients who do not or cannot give an informed consent. * Patients who have undergone surgery six weeks prior to liver transplantation. * Patients with known peripheral vascular disease. * Patients with an infection localized to the area of rIC-intervention * Patients with at a high risk or with previous history of multiple thrombo-embolic diseases. * Patients undergoing active immunosuppressive therapy

What they're measuring

Post-operative change in ALT

Timeframe: Day 0-4

Trial details

NCT IDNCT03758352

SponsorRigshospitalet, Denmark

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-06

View on ClinicalTrials.gov More Liver Transplant; Complications trials