The Effect of InTensive Statin in Ischemic Stroke With inTracranial Atherosclerotic Plaques (NCT03753555) | Clinical Trial Compass
RecruitingPhase 4
The Effect of InTensive Statin in Ischemic Stroke With inTracranial Atherosclerotic Plaques
China100 participantsStarted 2018-12-01
Plain-language summary
Intracranial atherosclerotic disease is the most common cause of ischemic stroke that is directly attributed to the progression or rupture of intracranial high-risk plaque in Asia. Many studies mainly from Euro-American population with a focus on extracranial carotid plaque have fully demonstrated the advantages of intensive statin therapy on stabilizing or reversing plaque burden, reversing plaque composition presenting that lipid-rich necrotic core (LRNC) is gradually replaced by fibrous tissue, and even reversing pattern of arterial remodeling to reduce the occurrence of cerebrovascular events. Yet, direct evidence of the effect of intensive statin therapy on intracranial atherosclerotic plaques is lacking and the effect of statin intensity and duration on intracranial plaque burden and composition is still unclear. High resolution magnetic resonance imaging (HRMRI) is a new and non-invasive technique that enable to assess the morphologic characteristics of vascular wall and plaque composition of intracranial artery. Based on above discussion, the investigators conduct this study to further determine the effect of intensive statin in ischemic stroke with intracranial atherosclerotic plaques.
Who can participate
Age range18 Years – 80 Years
SexALL
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Inclusion criteria
✓. Patient age between 18-80 years
✓. Time of onset: within 1 week
✓. NIHSS score ≤12
✓. Acute ischemic stroke confirmed by head CT or MRI
✓. Premorbid mRS ≤1
✓. The degree of stenosis of carotid artery, vertebral artery and intracranial portion of internal carotid artery on the lesion side \<50%
✓. The culprit plaque or possible culprit plaque with plaque burden of 40% or more found by HRMRI in the proximal part of the middle cerebral artery M1 segment or basilar artery of ipsilateral lesion