ENGAGE for Brain Health (NCT03750682) | Clinical Trial Compass
CompletedNot Applicable
ENGAGE for Brain Health
United States25 participantsStarted 2019-01-01
Plain-language summary
Age-related cognitive decline has a profound impact on the daily functioning of older adults, their families and healthcare systems. Despite its significant personal, societal and economic impact, no pharmacologic therapies presently exist to mitigate age-related cognitive decline. As the population of older adults continues to rapidly increase, the implementation of effective and scalable low-cost interventions that may maintain the cognitive independence of broad populations of older persons are now of urgent public health priority.
Who can participate
Age range
60 Years – 89 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* • Men and Women age 60-89 years, community-dwelling, ambulatory
* Presence of MCR syndrome
* Sedentary (reporting ≤ 20 min/week of regularly structured physical activity in the past month)
* Written permission from PCP for study participation
* Willingness to be randomized and participate for 24 weeks
Exclusion Criteria:
* • Acute or terminal illness
* Modified Mini-Mental State Examination Score \<80(\<76 if African American)\*
* Myocardial Infarction in the previous 6 months
* Symptomatic coronary artery disease
* Upper or lower extremity fracture in the previous 6 months
* Resting blood pressure \>180/100 mmHg
* Unable to communicate due to severe hearing loss or speech disorder
* Severe visual impairment that may preclude participation in the study assessments or interventions
* Non-English speaking
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Measuring the safety of a 6 month PA or HE intervention in a community setting in older adults with MCR
Timeframe: 6 Months
2
Measuring the success (feasibility) of integrating clinical exercise programs into real-world community-based settings.