Disorders of the Acute Phase Response Following Trauma and Invasive Surgery

Arm 1: Level I Trauma Patients Inclusion criteria * Any patient admitted to or treated in the VUMC Adult Trauma Unit * Patients ages 16 and older (all included in the adult trauma unit admissions) * Patients will be divided into sub-groups for analyses based on type of trauma (TBI, blunt force trauma, polytrauma, etc) and severity (Level 1 vs non-level 1 trauma) Exclusion criteria • None Arm 2: Invasive Elective Surgical Patients Inclusion criteria * Any patient admitted for an invasive elective surgery associated with high blood loss or a high risk of vascular complications at VUMC/VCH. Enrollment will be at the discretion of the attending physician * This may include, but is not limited to, orthopedic and vascular surgery patients * Patients ages 2 months and older Exclusion criteria * None Arm 3: Healthy Volunteers Inclusion criteria * Volunteers should be male or female * Age 18-70 years of age * Weight greater than 110lbs Exclusion criteria * Chronic medical conditions such as: diabetes, hypertension, high cholesterol, rheumatologic disorders, infections, etc. * No history of recent traumatic injury (within the past year) * Pregnant females or people on hormone replacement therapy * People on any anticoagulant medication or NSAIDS