Treatment of the Pancreatic Stump With Neoprene®-Based Glue After High-risk Pancreatoduodenectomy

Inclusion Criteria: * Patients with an alternative-Fistula Risk Score \>15%. * Patients with insulin-dependent diabetes. * Cirrhotic patients or with histologically proven chronic liver disease. * Age\> 75 years (relative criterion, ie insufficient by itself to justify the procedure and therefore to be associated with one of the other cited criteria). * Patients with intraoperative demonstration on histological examination of lymph node metastasis; * Patients with R1 interventions. * Presence of minimal extra-pancreatic tumor disease not detected pre-operatively (nodule of carcinosis, single liver metastasis) and removed with the primary tumor within the same intervention; * Patients undergoing preoperative radiotherapy / chemotherapy for tumors reconverted to surgical operability. Exclusion Criteria: * All other patients who undergo PD in which the eligibility conditions for the study group are not present, are enrolled in the Control Arm..