CompletedNot Applicable

Tumor Microenvironment in Patients With Localized Osteosarcoma Treated With Mifamurtide: a Translational Study

Italy80 participantsStarted 2018-12-12

Plain-language summary

International, multicenter retrospecitve biological study

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

✓. Patients with primary localized osteosarcoma who received chemotherapy +/- mifamurtide according to ISG-OS2/GEIS-33 trials,
✓. Paraffin-embedded tissue tumor (FFPE) blocks from archive available to perform the biological analysis
✓. Written informed consent prior to any study-specific analysis and/or data collection

Characterize the immunephenotype in patients with localized osteosarcoma treated with chemotherapy +/- mifamurtide for primary osteosarcoma

Timeframe: at baseline (Day0)

Correlate the rate of immune cells, and the level of the PDL-1 checkpoint with event-free survival and overall-survival

Timeframe: at baseline (Day0)

NCT IDNCT03737435

SponsorIstituto Ortopedico Rizzoli

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2024-10-25