CompletedEarly Phase 1

Bilateral Ultrasound Guided Pectoralis Nerve Block Induces Hemodynamic Stability With Reducing Systemic Stress Response for Off-pump Coronary Artery Bypass Graft

Egypt40 participantsStarted 2016-01

Plain-language summary

Opioids used in attenuation of the neuroendocrine stress response in patients undergoing off-pump coronary artery bypass graft (OPCAB) it produces predictable satisfactory analgesia and sedation but with side effects such as respiratory depression, drowsiness, and myocardial depression. Regional techniques may be encouraged to be anti-stress procedures and produce risk-free postoperative (OPCAB) period. Pectoralis nerve block (pecs block) appears to possess a great deal of promise for patients undergoing (OPCAB) because of low complication rates as it is less invasive regional analgesic technique when compared to paravertebral, thoracic epidural analgesia and parenteral analgesia.

Who can participate

Age range45 Years – 75 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * patients undergoing first-time OPCAB surgery. * patients with good or only slightly reduced left ventricular function (ejection fraction \_40%, left ventricular end-diastolic pressure \_15 mmHg) * patients below 75years of age Exclusion Criteria: * patients requiring CPB either electively or during the course of surgery * patients with renal insufficiency (creatinine \_1.5 mg/dL) or hepatic impairment (alanine aminotransferase or aspartate aminotransferase \_40 U/mL) * patients who misused alcohol or drugs * patients with hemodynamic instability * symptoms of congestive cardiac failure * preexisting infection at the block site * allergy to local anesthetics * psychiatric illness * patients with prolonged postoperative ventilator course

What they're measuring

1

Changes in Heart rate.

Timeframe: Basically (T0),immediately before the induction of anesthesia; (T1), immediately after tracheal intubation; (T2),immediately after sternotomy;( T3), 30 minutes after the start of surgery; and (T4), immediately at the end of surgery

2

changes in mean arterial blood pressure and cardiac indices.

Timeframe: Basically (T0),immediately before the induction of anesthesia; (T1), immediately after tracheal intubation; (T2),immediately after sternotomy;( T3), 30 minutes after the start of surgery; and (T4),immediately at the end of surgery

3

changes in cardiac indices.

Timeframe: Basically (T0),immediately before the induction of anesthesia; (T1), immediately after tracheal intubation; (T2),immediately after sternotomy;( T3), 30 minutes after the start of surgery; and (T4),immediately at the end of surgery

4

changes in Plasma levels of adrenocorticotropic hormone(ACTH) .

Timeframe: Basically (T0),immediately before the induction of anesthesia; (T1), immediately after tracheal intubation; (T2),immediately after sternotomy;( T3), 30 minutes after the start of surgery; and (T4),immediately at the end of surgery

5

changes in Plasma levels of cortisol hormone

Timeframe: Basically (T0),immediately before the induction of anesthesia; (T1), immediately after tracheal intubation; (T2),immediately after sternotomy;( T3), 30 minutes after the start of surgery; and (T4), immediately at the end of surgery

Trial details

NCT IDNCT03734848

SponsorTanta University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2018-01