"Cross" Closure for Reconstructing the Perineal Wound of Abdominoperineal Resection (NCT03731754) | Clinical Trial Compass
UnknownNot Applicable
"Cross" Closure for Reconstructing the Perineal Wound of Abdominoperineal Resection
346 participantsStarted 2018-11-20
Plain-language summary
How to reduce the complications of perineal wound after abdominoperineal resection (APR) has always been a hot topic in the medical field.To reduce the complications of perineal wound and the primary healing of perineal wound must meet the two principles of "unobstructed drainage" and " reduced tension closure".This concept is similar to the concepts of closure of enterostomy in rectal cancer patients. It was reported that use of cross-stitch closure can significantly reduce complications of closure of enterostomy. So the investigator ever used the "cross" closure to reconstruct the perineal wound of APR, which was really decrease the complications of perineal wound. However, more clinical trails was needed to confirm the conclusion.
Who can participate
Age range18 Years – 75 Years
SexALL
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Inclusion criteria
✓. Age: 18-75 years old;
✓. ECOG performance status: 0-2;
✓. Histologically confirmed rectal cancer or anal canal cancer;
✓. Completely resected the primary tumor;
✓. No evidence of distant metastasis;
✓. Tolerable general anesthesia;
✓. Total radiation dose of 45-50 Gy needed if the patient needs to receive routine segmental radiotherapy;
✓. Provision of written informed consent.
Exclusion criteria
✕. Emergency surgery required when the patients combined with acute ileus, perforation and hemorrhage;