American Ginseng for the Prevention of Moderate-severe Fatigue in Breast Cancer Patients

Inclusion Criteria: * submitted for the first time to adjuvant chemotherapy with anthracyclines and cyclophosphamide after surgery for breast cancer; * not presenting CRF or at least with o al massimo CRF lieve (NRS \< 4); * 18 year old, who have given written informermed consent; * who accept to use adequate contraceptive methods, if they are of child-bearing potential. Exclusion Criteria: * previously submitted to chemotherapy; * with concomitant not-correctable alterations, present before chemotherapy, possible determinants of fatigue (NRS ≥ 4), such as anemia, not well controlled pain, insomnia, electrolyte imbalance, dehydration, anorexia/cachexia, hepatic, renal or heart failure, adrenocortical failure, neurological deficit, hypothyroidism, not-controlled diabetes mellitus; * submitted to raitherapy during the 15 days before the randomization; * presenting moderate-severe fatigue (NRS ≥ 4) at basaline; * receivind opioids or corticosteroids (except if admimistered at phisiological doses or to prevent emesis on the chemotherapy day); * with with blood cell count \< 3000/mm3, platelets \< 70000 mm3, hemoglobin \< 8 g/dL; * unable to understand the procedures of the study or to collaborate with them; * pregnant or breastfeeding.