UnknownNot Applicable

Offsetting Hippocampal Degeneration in m-sTBI

Canada25 participantsStarted 2019-07-25

Plain-language summary

The goal of this study is to establish the feasibility of an intervention designed to improve memory in patients who have experienced a moderate or severe traumatic brain injury (m-sTBI) and to examine its effect on brain structures.

Who can participate

Age range18 Years – 65 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * An acute care diagnosis of TBI as determined by a medical professional, indicated by: * Post-traumatic amnesia duration of 24 hours or more, and/or lowest Glasgow Coma Scale score of \< 13 * Positive clinical CT or MRI scan * Aged 18 to 65 * Fluent in English * Have the competency for fully informed consent by 6 months post-injury * Have basic computer skills * Have functional use of one upper extremity * Have access to the internet Exclusion Criteria: * A neurological disorder other than TBI (e.g., stroke, dementia, tumor, neurodevelopmental disorder) impairing baseline awareness, cognition, or validity of follow-up and outcome assessment. * A systemic condition (e.g., lupus, diabetes, rheumatoid arthritis). * Any contraindications to magnetic resonance imaging (MRI) * You are experiencing language impairments (i.e., aphasia) from your injury

What they're measuring

Online Spatial Navigation Intervention Test Scores: Change in Spatial Learning Ability

Timeframe: Time-point 1: 7 months post-injury and Time-point 2: 12 months post-injury

Online Spatial Navigation Intervention Test Scores: Change in Cognitive Map Formation

Timeframe: Time-point 1: 7 months post-injury and Time-point 2: 12 months post-injury

Online Spatial Navigation Intervention Test Scores: Change in Pattern Separation

Timeframe: Time-point 1: 7 months post-injury and Time-point 2: 12 months post-injury

Online Spatial Navigation Intervention Test Scores: Change in Pattern Completion

Timeframe: Time-point 1: 7 months post-injury and Time-point 2: 12 months post-injury

Trial details

NCT IDNCT03727334

SponsorUniversity of British Columbia

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-07

Contact for this trial

Nishtha Parag, BSc

604-418-4160 nishthap@psych.ubc.ca

View on ClinicalTrials.gov More Traumatic Brain Injury trials