Propranolol, Carvedilol and Rosuvastatin in the Prevention of Variceal Bleeding in Cirrhotic Portal Hypertension

Inclusion Criteria: * Hepatic cirrhosis of any etiology * Previous variceal bleeding * Endoscopic variceal eradication at least 2 weeks before Exclusion Criteria: * Beta blocker or statin contraindications * Model for End-Stage Liver Disease (MELD) score \> 25 * Child-Pugh score \> 13 * HVPG ≤ 12 mmHg * Creatinine clearance \< 50 mL/min * Refractory ascites * Hepatic encephalopathy stages 3 or 4 * Alcohol use in the last 6 months * Hepatitis C treatment in the last 6 months * Changing or initiating a new hepatitis B treatment in the last 6 months * Malignant neoplasms from any origin except basal cell carcinoma * HIV infection * Pregnancy * Anticoagulation * Recent or complete portal vein thrombosis