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Stroke Imaging Package Study of Intracranial Atherosclerosis ( SIPS-ICAS )

China550 participantsStarted 2018-11-14

Plain-language summary

A prospective, multicenter, cohort study to explore the stroke mechanisms of symptomatic intracranial atherosclerosis, the dynamic changes under aggressive medical treatment and their associations with clinical events using conventional MRI sequences plus high-resolution magnetic resonance (HR-MRI).

Who can participate

Age range35 Years – 80 Years

SexALL

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Inclusion criteria

✓. Age 35-80 years old
✓. First-ever stroke patients confirmed by diffusion weighted imaging (DWI) attributed to intracranial artery stenosis (\> 50%) within 7 days after onset.
✓. Patients with stable vital signs.
✓. Patients who have underwent thrombolytic/intravascular therapy are allowed to enroll in the study.

Exclusion criteria

✕. Patients with \> 50% ipsilateral carotid artery stenosis, cardiac embolism ,and any other stroke etiologies such as vasculitis, dissection or other causes.
✕. Patients with absolute/relative contraindication to MRI (including but not confined to metal in the body and claustrophobia).
✕. Patients who cannot comply with MRI exam.
✕. Patients who decline the consent.

What they're measuring

poor functional outcome

Timeframe: 90 day after stroke onset

Number of Participants with stroke recurrence

Timeframe: 12 months after stroke onset

Evolution of intracranial atherosclerosis burden

Timeframe: 6 months after stroke onset

Trial details

NCT IDNCT03719820

SponsorWei-Hai Xu

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2020-12-31

Contact for this trial

Weihai Xu, MD

010-69156114 xuwh@pumch.cn

View on ClinicalTrials.gov More Acute Ischemic Stroke AIS trials