CompletedNot Applicable

NORepinephrine-Maintaining-individuaALIZEd Blood Pressure

South Korea420 participantsStarted 2018-11-01

Plain-language summary

This study compares the effect of individualized vs standard blood pressure management on postoperative myocardial injury in high-risk patients undergoing non-cardiac surgery by measuring the hs-cTnT levels. Continuous norepinephrine infusion is used to target a mean pressure of greater than 65mmHg and a systolic pressure less than 160mmHg in the standardized group while the target is 20% within the ward blood pressure in the individualized group. The pre- and postoperative hs-cTnT levels to detect myocardial injury are compared between the two groups.

Who can participate

Age range20 Years – 80 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients scheduled for general or urologic surgeries under general anesthesia at Seoul National University Hospital * high-risk patients with a revised cardiac risk index of at least 2 points or more Exclusion Criteria: * severely uncontrolled hypertension (systolic blood pressure ≥ 180mmHg or mean blood pressure ≥ 110) * severely uncontrolled hypotension (systolic blood pressure \< 80mmHg) * arrhythmias with symptoms or use of pacemaker * transplantation surgery * acute or decompensated heart failure * acute coronary syndrome * sepsis * end stage renal disease (GFR \<30ml/min/1.73m2) * contraindications of norepinephrine infusion

What they're measuring

Occurrence of postoperative myocardial injury

Timeframe: baseline and postoperative day 1

Trial details

NCT IDNCT03715712

SponsorSeoul National University Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-05-28

View on ClinicalTrials.gov More Perioperative Myocardial Injury trials