TerminatedPhase 4

Comparison of Dexamethasone Oral Preparations to Assess Taste and Acceptance in Children With Asthma and Croup

Stopped: Dr. Arnold assisted in designing and initiating study for a pharmacology PhD candidate. The candidate left the institution and study enrollment was terminated.

United States40 participantsStarted 2018-10-23

Plain-language summary

Study of the palatability and acceptability of dexamethasone oral tablets crushed and placed in apple sauce or pudding in comparison with the IV solution mixed with sugar syrup and given orally. It is hypothesized that dexamethasone tablets crushed and administered in apple sauce or pudding will be more palatable and acceptable for pediatric patients receiving dexamethasone for an acute asthma exacerbation or croup.

Who can participate

Age range1 Year – 7 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Diagnosis of acute asthma exacerbation or croup (laryngotracheitis) in the Vanderbilt Children's Hospital Emergency Department * Age 1 to 7 years * Dexamethasone treatment indicated * No other acute or chronic process accounting for signs and symptoms (e.g., foreign body aspiration, pneumonia, cystic fibrosis) * Have not received systemic corticosteroid for current episode prior to enrollment Exclusion Criteria: * Allergy to dexamethasone or apple sauce and pudding * Unable to take medication orally

What they're measuring

Number of Participants With Nausea

Timeframe: 1 hour

Trial details

NCT IDNCT03705273

SponsorVanderbilt University Medical Center

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2020-10-02

Results submitted2021-09-13

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