Immunogenetic Modulators of Mucosal Protection From HIV-1

Inclusion criteria: HIV-1 Uninfected Participants; * Age ≥18 and ≤65 and able to provide independent informed consent for research per local regulations and guidelines * Able and willing to provide written informed consent to be screened for and to take part in the study * Part of a heterosexual couple in which either one or both partners meet the study eligibility criteria for partner (HIV-1 uninfected) participants. Couples are defined by the following criteria: * Partners are sexually active (defined as having had vaginal intercourse with the enrolled partner at least 6 times in the last three months) * Partners plan to remain in the relationship for the duration of the study period. * HIV-1 uninfected status is based on parallel negative HIV-1 rapid tests, both at study screening and at the enrollment visit * Able and willing to provide adequate locator information for study retention purposes, as defined by local standard operating procedures HIV-1 Infected Participants; * Of legal age to provide independent informed consent for research per local regulations and guidelines. * Able and willing to provide written informed consent to be screened for and to take part in the study. * Part of a heterosexual couple in which one partner meets the study eligibility criteria for index (HIV-1 infected) participants and the other partner meets the study eligibility criteria for partner (HIV-1 uninfected) participants * Current or previous use of antiretroviral therapy with unsu…