MoleMapper, Visiomed, and Confocal Microscopy in Screening Participants for Melanoma

Inclusion Criteria: * Persons who participate in the free skin cancer screening at the PDX Skincare Festival at Oregon Health \& Science University (OHSU) in 2021/2022 (date pending) and are informed by a provider that they have a pigmented lesion for which a biopsy is recommended are potentially eligible to participate in this study. * Persons who participate in the free skin cancer screening at the War on Skin Cancer event at OHSU in 2021/2022 (date pending) or other dates and locations and are informed by a provider that they have a clinically benign or atypical nevi are eligible to participate in the imaging portion of this study. No biopsy will be offered to these participants. * Persons age 18-80 are eligible for the study * Persons of any sex can be enrolled. * Persons of any race are eligible but we anticipate that most participants will be Non-Hispanic whites due to the prevalence of melanoma and other skin cancers in this group. * Only persons who can provide signed statement of informed consent will be enrolled. * Persons who are identified in OHSU Dermatology clinics or through OHSU e-visit and e-consult platforms as having a skin lesion in need of a biopsy for skin cancer * Persons identified via the Melanoma Community Registry (MCR) (IRB approved: 00010561) Exclusion Criteria: * Allergy to the anesthetic (lidocaine).