Visualizing Vascular Mechanisms of Salt Sensitivity (NCT03696433) | Clinical Trial Compass
CompletedNot Applicable
Visualizing Vascular Mechanisms of Salt Sensitivity
United States19 participantsStarted 2019-02-01
Plain-language summary
This study aims to assess the salt sensitive blood pressure response to dietary salt load compared with radiological markers of salt handling.
Who can participate
Age range
18 Years – 55 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Identification as black race
* Age between 18 and 55 years
* Body mass index between 25 and \<35 kg/m2
* Normotensive or pre-hypertensive
* Willing to adhere to study diets
* Able to provide informed consent and communicate with study personnel
Exclusion Criteria:
* Prevalent cardiovascular disease or use of medications for cardiovascular disease
* Current or prior history of hypertension or use of blood pressure lowering medications
* Current or prior history of diabetes mellitus or use of anti-diabetic medications
* Prevalent renal disease (eGFR \< 60 ml/min/1.73m2), abnormal serum sodium or potassium
* Current or prior smoker
* Current pregnancy, or use of hormone replacement therapy or oral contraceptive
* Current steroid use
* Contraindications to MRI
* Active infection or open wounds on the top of the feet or hands
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This study looked at how salt intake affects blood pressure in people with obesity — given my own weight and blood pressure history, would the findings from this kind of research change anything about the amount of salt my doctor recommends for me?
2The trial compared blood pressure responses to a high-salt versus a low-salt diet — does my doctor think I'm likely to be 'salt-sensitive,' and is that something we should actually test or monitor in my care?
3Since this trial is now completed, has my doctor seen any published results from it, and if so, do those findings suggest anything practical about diet changes I should consider?
4This study focused on vascular mechanisms — meaning how blood vessels respond to salt — so should I be asking about any imaging or vascular tests to understand my own cardiovascular risk related to salt intake?
5Given that this was a research study rather than a treatment trial, are there any current standard-of-care guidelines about salt restriction for someone with my health profile that my doctor would recommend I follow right now?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Mean Arterial Blood Pressure Following High-salt Diet and Low-salt Diet
Timeframe: Following completion of all dietary supplements and washout, in no less than 21 days.