This study evaluates the utility of placental/umbilical cord blood (PUCB) to perform the baseline workup testing for EONS in Very Low Birth Weight Infants: CBC (Complete Blood Count) with differential, Immature/Total ratio (I/T ratio), and blood culture along with CRP and IL-6 levels. A cohort (63 subjects) of preterm infants will be recruited. All the participants will be evaluated for sepsis using placental/umbilical cord blood (PUCB) and subject blood sample during the first 12 hours of life (after birth).
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White Blood Cell Count (WBC) (1)
Timeframe: Completed during the first 30 minutes after birth. This sample is going to be taken from the discarded Placental/umbilical blood cord.
White Blood Cell Count (WBC) (1) INFANT BLOOD
Timeframe: Completed during the first 6 hours after birth. This sample is going to be taken directly from the participant.
I/T Ratio (Immature/Total Immature Neutrophil).I/T Ratio Was Calculated by Dividing Immature White Cell Count Total White Cell Count
Timeframe: Completed during the first 30 minutes after birth. This sample is going to be taken from the discarded Placental/umbilical blood cord.
I/T Ratio (Immature/Total Immature Neutrophil Ratio) INFANT BLOOD
Timeframe: Completed during the first 12 hours after birth. This sample is going to be taken directly from the participant.
CRP (C-Reactive Protein)(1)
Timeframe: Completed during the first 30 minutes after birth. This sample is going to be taken from the discarded Placental/umbilical blood cord.
CRP (C-Reactive Protein)(2) INFANT BLOOD
Timeframe: Completed during the first 6 hours after birth. This sample was taken directly from the participant.
IL-6 (1)
Timeframe: Completed during the first 30 minutes after birth. This sample is going to be taken from the discarded Placental/umbilical blood cord.
IL-6 (Interleukin-6) INFANTS BLOOD
Timeframe: Completed during the first 6hours after birth. This sample is going to be taken directly from the participant.
Procalcitonin PUBC
Timeframe: Within 30 minutes after delivery
Procalcitonin Level Was Measured in the Blood From Placenta and From the Baby Within 6 Hours After Birth
Timeframe: Procalcitonin Level was measured in the blood from placenta and in Infant's Blood (within 6 hours)
Number of Participants With Negative Blood Culture From Blood Drawn From Placenta and From Baby Within 6 Hours After Birth
Timeframe: Blood sample drawn from placenta and from baby within 6 hours after birth.
Presepsin- PUBC
Timeframe: First 30 min after birth
Presepsin-Infant's Blood
Timeframe: First 30 min after birth
Number of Participants With a Negative Blood Culture
Timeframe: first 2 hours after birth