CompletedNot Applicable

Brain Excitability and Connectivity in Sensory-motor Pathways in ALS

France52 participantsStarted 2018-11-26

Plain-language summary

The main objective is to determine the origin of somatosensory alteration in patients with ALS and to evaluate its impact on brain activity by coupling different imaging modalities and indirect electrophysiology. The secondary objective is to evaluate whether the observed functional changes in MEG / EEG and functional MRI correlate with structural lesions revealed with diffusion MRI (anatomo-functional connectivity of the brain).

Who can participate

Age range30 Years – 80 Years

SexALL

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Inclusion Criteria: * ALS, MRC score ≥ 4 at least in one hand * Controls: no history of neurological disorders, right-handed Exclusion Criteria: * contraindication to MRI

What they're measuring

Brain activity

Timeframe: 1 hour

Trial details

NCT IDNCT03694132

SponsorInstitut National de la Santé Et de la Recherche Médicale, France

Sponsor typeOTHER_GOV

Study typeINTERVENTIONAL

Primary completion2019-12-31

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