CompletedNot Applicable

The Cardiovascular Effects of Electronic Hookah Vaping

United States19 participantsStarted 2018-12-11

Plain-language summary

Hookah (water-pipe) tobacco smoking has quickly grown to become a major global tobacco epidemic among youth; with electronic (e-) hookahs more recently increasing in popularity especially among young female adults, who endorse marketing claims that these products are a safer alternative to traditional hookah, but scientific evidence is lacking. The study aims to elucidate the comparative effects of traditional hookah smoking vs. e-hookah vaping on human vascular and endothelial function; and examine the role of inflammation and oxidative stress, as likely mechanisms in hookah-related cardiovascular disease pathogenesis.

Who can participate

Age range

21 Years – 39 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * 21-39 years old hookah smokers: smoked hookah \>12x in last 12 months * no history of illicit drugs or marijuana * no evidence of cardiopulmonary disease by history/ physical * no diabetes: fasting blood glucose \<100 mg/dl * BP\<140/90mmHg * resting HR\<100 bpm * BMI\<30kg•m2 * no prescription medication Exclusion Criteria: * exhaled CO\>10 ppm (smoking non-abstinence) * positive pregnancy test * psychiatric illness

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Flow-Mediated Dilation (FMD)

Timeframe: Pre- and post- the 30-minute smoking or vaping exposure sessions

Carotid-Femoral Pulse Wave Velocity (Cf-PWV)

Timeframe: Pre- and post- the 30-minute smoking or vaping exposure sessions

HDL Oxidant Index (HOI)

Timeframe: Pre- and post- the 30-minute smoking or vaping exposure sessions

Paraoxonase-1 (PON-1) Activity

Timeframe: Pre- and post- the 30-minute smoking or vaping exposure sessions

Arylesterase Activity

Timeframe: Pre- and post- the 30-minute smoking or vaping exposure sessions.

High-sensitivity C-reactive Protein (Hs-CRP) Levels

Timeframe: Pre- and post- the 30-minute smoking or vaping exposure sessions

Tumor Necrosis Factor-α (TNFα) Concentrations

Timeframe: Pre- and post- the 30-minute smoking or vaping exposure sessions

Trial details

NCT IDNCT03690427

SponsorUniversity of California, Los Angeles

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2021-08-31

Results submitted2023-05-27

View on ClinicalTrials.gov More Endothelial Dysfunction trials

Plain-language summary

Who can participate

Age range

21 Years – 39 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Flow-Mediated Dilation (FMD)

Timeframe: Pre- and post- the 30-minute smoking or vaping exposure sessions

Carotid-Femoral Pulse Wave Velocity (Cf-PWV)

Timeframe: Pre- and post- the 30-minute smoking or vaping exposure sessions

HDL Oxidant Index (HOI)

Timeframe: Pre- and post- the 30-minute smoking or vaping exposure sessions

Paraoxonase-1 (PON-1) Activity

Timeframe: Pre- and post- the 30-minute smoking or vaping exposure sessions

Arylesterase Activity

Timeframe: Pre- and post- the 30-minute smoking or vaping exposure sessions.

High-sensitivity C-reactive Protein (Hs-CRP) Levels

Timeframe: Pre- and post- the 30-minute smoking or vaping exposure sessions

Tumor Necrosis Factor-α (TNFα) Concentrations

Timeframe: Pre- and post- the 30-minute smoking or vaping exposure sessions