Predicting Progression of Developing Myeloma in a High-Risk Screened Population (PROMISE)

Inclusion Criteria for Cohort 1: * Age ≥ 30 years * AA race (self-identified) and/or first-degree relative of a patient with a plasma cell dyscrasia such as MGUS, SMM, MM, and Waldenström's Macroglobulinemia, or another blood cancer. OR • Those over 18 are also eligible if they have 2 or more family members with a blood cancer Inclusion Criteria for Cohort 2A: Screened positive by mass spectrometry in the Ghobrial Lab for SMM or MGUS as part of the Mass General Brigham Biobank arm AND fits one of the following two groups of criteria: * Age ≥ 30 years * AA race (self-identified) and/or first-degree relative of a patient with a plasma cell dyscrasia such as MGUS, SMM, MM, and Waldenström's Macroglobulinemia, or another blood cancer. OR • Those over 18 are also eligible if they have 2 or more family members with a blood cancer Inclusion Criteria for Cohort 2B: Screened positive by mass spectrometry in the Ghobrial Lab for SMM or MGUS as part of the Mass General Brigham Biobank arm AND fits the criteria listed below: • Age ≥ 18 years Exclusion Criteria for Cohort 1: * Persons diagnosed with cancer at any site (including hematologic cancers) with symptomatic disease requiring active therapy. * Persons with an already diagnosed plasma cell dyscrasia such as MGUS, SMM, MM, and Waldenström's Macroglobulinemia Exclusion Criteria for Cohort 2A and 2B: * Persons under the age of 18 years old First-degree relatives would not need to be identified by the participant. This …