Effects of Emotion on Episodic Memory in Typically Developing Children and Children With Williams… (NCT03688516) | Clinical Trial Compass
CompletedNot Applicable
Effects of Emotion on Episodic Memory in Typically Developing Children and Children With Williams-Beuren Syndrome
France280 participantsStarted 2018-06-28
Plain-language summary
It's well established in the literature that emotional events are more likely to be remembered than neutral events. Although this Emotional Enhancement of Memory (EEM) has been well demonstrated in the adult literature, little is known about EEM for typically developing children and children with Williams-Beuren syndrome (WBS). In this study, two investigations will be conducted concomitantly: one of EEM in typically developing children and the other of EEM in children with WBS. For this purpose, three behavioral experiments will be established to investigate EEM in this two populations, with the first experiment also including electroencephalography measures. Performances of typically developing children will be compared to young adults, and performances of children with WBS will be compared to control children matched for mental age. Finally, this study aims to bring new knowledge about the interactions between emotion and memory in children, and to better understand cognitive functioning in children with WBS.
Who can participate
Age range
6 Years – 30 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
Children with William-Beuren syndrome
* Genetic diagnosis (CGH-Array or FISH) of microdeletion 7q11.23
* 8 to 18 years old
* Native French speaker
* Psychotropic medication unchanged during one month preceding inclusion
Typically developing children and healthy adults:
* 6 to 30 years old
* Native French speaker
* Absence of history of neurodevelopmental neurological and psychiatric disease
Exclusion Criteria:
Children with William-Beuren syndrome:
* Diagnosis of severe intellectual deficit (Total IQ lower than 40 evaluated with WPPSI-II or WISC-IV)
* Presence of another genetic anomaly
* Presence of vascular; infectious or neurodegenerative disease
* Medication impacting motor and cognitive abilities
* Non-corrected visual and hearing impairment
Typically developing children and Healthy Adults :
* Diagnosis of severe intellectual deficit (Total IQ lower than 70 evaluated with WPPSI-II or WISC-IV)
* Presence of vascular; infectious or neurodegenerative disease knew by parents or legal representative
* Learning disorders
* History of neurological or psychiatric disease
* Medication impacting motor and cognitive abilities, non-corrected visual and hearing impairment
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Manipulation of Valence
Timeframe: During the presentation of the stimuli or just after the presentation of the stimuli