CompletedPhase 2

Sildenafil for Swimming-Induced Pulmonary Edema (SIPE) Prevention

United States18 participantsStarted 2019-07-15

Plain-language summary

This trial is testing the effectiveness of a single oral dose of sildenafil (50 mg) taken 1 hour before a provocative event on the subsequent development of swimming-induced pulmonary edema.

Who can participate

Age range18 Years – 45 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Healthy volunteers between 18 and 45 years * History of swimming-induced pulmonary edema Exclusion Criteria: * Pregnant women * Significant heart valve disease * Cardiomyopathy * Uncontrolled hypertension * Coronary artery disease * Obstructive lung disease * VO2max \<25 mL/kg as estimated by the University of Houston Non-Exercise Test * Previous adverse reaction to sildenafil * Use of antihypertensives or other drugs that are known to interact adversely with sildenafil (e.g. nitrates, alpha adrenergic blockers)

What they're measuring

Number of Participants With Pulmonary Edema

Timeframe: During or immediately after exercise in cold water, approximately one hour and 40 minutes

Trial details

NCT IDNCT03686813

SponsorDuke University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2021-10-29

Results submitted2022-10-28

View on ClinicalTrials.gov More Edema, Pulmonary trials