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The Compliance and Prognosis of NSBB Secondary Prevention of Cirrhosis With Gastroesophageal Varices Bleeding

China90 participantsStarted 2018-07-01

Plain-language summary

Non-selective beta blockers are commonly used drugs for primary prevention and secondary prevention in patients with cirrhotic decompensated esophageal varices bleeding，the basic heart rate, blood pressure and condition of different patients have individual differences.This paper mainly discusses the compliance of patients taking NSBB under different follow-up methods and analyze the factors affecting patient compliance.

Who can participate

SexALL

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Inclusion criteria

✓. Signed informed consent
✓. All cases met the diagnostic criteria for cirrhosis
✓. All patients were confirmed to be combined with esophageal and gastric varices through endoscopy or portal vein CTA or abdominal CT, and had at least one history of esophageal and gastric varices rupture and bleeding. Child-pugh was graded as A/B.
✓. All patients had basal heart rate greater than 60 beats/min and systolic pressure greater than 90mmhg.

Exclusion criteria

✕. Patients with liver cancer or other gastrointestinal tumors
✕. Patients with splenomegaly due to extrahepatic portal hypertension and noncirrhosis
✕. Patients with basal heart rate less than 55 beats/min or systolic pressure less than 90mmhg
✕. There are patients with NSBB contraindications such as severe cardiac insufficiency, cardiogenic shock, sinus bradycardia and morbid sinus syndrome, severe ventricular conduction block, bronchial asthma, etc.
✕. Patients with other diseases other than liver cirrhosis should take beta blockers (such as coronary heart disease, arrhythmia, etc.).
✕. Patient data is incomplete, data cannot be collected and counted
✕. Patients who do not agree with secondary prevention after informing them about the adverse reactions associated with medication

What they're measuring

Heart rate compliance ratio after treatment with NSBBs

Timeframe: 10 months

Trial details

NCT IDNCT03683121

SponsorRenmin Hospital of Wuhan University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2021-12-31

View on ClinicalTrials.gov More Esophageal Varices Bleeding trials