Clinical Study Using Biologics to Improve Multi OIT Outcomes (COMBINE)

Inclusion Criteria: * Age 4 through 55 years (inclusive). * Clinical history of peanut allergy and 1 or 2 additional foods from the following foods: milk, almond, shellfish, fish, cashew, hazelnut, egg, walnut, sesame seeds, soy, and wheat. Allergy to milk and egg is defined as unable to tolerate both cooked and uncooked forms. * Positive allergy test determined by: * ImmunoCAP serum IgE level \>4 kilo Units of allergen per Liter (kUA/L) for each allergen within the past 12 months OR * Skin prick test (SPT) ≥6 mm wheal diameter to each allergen. * A clinical reaction during a DBPCFC to small doses of food defined as a cumulative dose of =/\<444 mg food protein. * No clinical reaction observed during the placebo (oat) challenge. * Subject and/or parent guardian must be able to understand and provide informed consent. * Written informed consent from adult participants. * Written informed consent from parent/guardian for minor participants. * Written assent from minor participants as appropriate (e.g., at and above the age of 7 years). * Use of effective birth control by female participants of childbearing potential. Exclusion Criteria: * History of cardiovascular disease, including uncontrolled or inadequately controlled hypertension. * Individuals less than 15 kg in weight at start of the study * History of severe anaphylaxis to participant-specific foods that will be used in this study, defined as neurological compromise or requiring intubation. * History of chronic diseas…